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A recent study by the National Institute of Health (NIH) and the National Institutes of Health (NIH) found that men with erectile dysfunction (ED) are twice as likely to experience premature ejaculation than men without ED.

Researchers looked at nearly 1,000 men in the United States who were taking or were taking drugs called selective serotonin reuptake inhibitors (SSRIs) and found that nearly two-thirds experienced a statistically significant increase in the frequency of men with ED. These men had low sex drive or an erection that was painful to have sexual contact.

Researchers also found that men who were taking SSRIs had a 69 percent higher frequency of PE than men who were taking a placebo group. They found that men with ED were twice as likely to have been diagnosed with premature ejaculation than men without ED. The increase was especially pronounced in men who were older than 40 or taking antidepressants.

But the researchers found that this difference in the men’s performance was not due to SSRIs’ higher incidence of premature ejaculation. “The finding that men who were taking SSRIs were twice as likely to have PE than men who were taking a placebo is an interesting finding,” lead author Robert Kesselheim, from the Massachusetts Male Aging Study, told the paper in an interview with.

“The fact that men who were taking SSRIs were twice as likely to have PE than men who were taking a placebo is significant because it suggests that men may have a higher incidence of PE when they have ED than when they are on antidepressants,” Kesselheim added. “This finding is consistent with the theory that selective serotonin reuptake inhibitors, such as Viagra, increase the amount of serotonin in the brain, which can help delay ejaculation.”

Although the researchers note that the increased serotonin levels in the brain are thought to be a marker of ED, they point out that other studies have found no association between SSRIs and PE. They also note that men taking SSRIs are more likely to report sexual dysfunction, and that this effect is more pronounced among men with low sex drive.

Kesselheim adds that his research was “very preliminary, and so there was no clear association with PE.”

The authors of the study noted that men taking SSRIs had a 69 percent higher frequency of premature ejaculation than men taking a placebo. However, they note that the researchers did not examine the impact of these sexual problems on men’s sexual performance.

“We found that men who were taking SSRIs were twice as likely to have PE as men who were taking a placebo, but this is an interesting finding because it suggests that men may have a higher incidence of PE when they have ED than when they are on antidepressants,” Kesselheim added.

The research also found that men who were taking SSRIs were twice as likely to have been diagnosed with premature ejaculation than men who were taking a placebo. However, the researchers did not examine the impact of these sexual problems on men’s sexual performance.

Kesselheim also noted that the researchers had not studied the impact of sexual problems on men’s sexual performance. The study was conducted at the University of Miami School of Medicine and was funded by the National Institute of Mental Health. Kesselheim and his colleagues did not return a request for comment.

Citation: A study found that men with erectile dysfunction (ED) are twice as likely to experience premature ejaculation (2021, January 28) retrieved 26 Apr 2025 from https://medicalxpress.com/news/2021-01-a-study-found-men-with-erectile-dysfunction-premature-epis

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

may be used for research only.©2021 Priya S, Kesselheim J, Kesselheim S (2021). Priya S, Kesselheim J, Kesselheim S (2021).

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Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

  • The usual starting dose is 50mg, taken approximately one hour before sexual activity.
  • Dosage can be adjusted depending on individual response and tolerability.
  • Take only one tablet in 24 hours, with or without food.
  • Avoid grapefruit juice, as it can increase the risk of side effects.
  • A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

  • Taking nitrates for chest pain
  • With severe heart or liver conditions
  • Under 18 years of age
  • With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

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  • Alpha-blockers
  • Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

  • Generic versions are more affordable than branded Viagra.
  • Supplied by licensed UK pharmacies such as Online Chemist.
  • Avoid counterfeit products from unregulated websites.

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